Outline:

With this webinar series we want to update you with latest research highlights in the pharmaceutical manufacturing field. Covid-19 made it impossible for us to welcome you in Graz therefore we want to take this opportunity to show you the advancements we made in the field of continuous manufacturing. Our top RCPE researchers will present to you, recent work that we generated in the field of continuous manufacturing and material science. The webinars will be released at the given date at 04:00 PM CEST. They will remain accessible at any time and can be viewed whenever it suits you best.

Schedule:

Validation of a ConsiGma® Tablet Coater Digital Twin

06.07.2021 – 04:00 PM CEST

Using CFD-DEM coupling models were developed for the simulation of the coating process inside a ConsiGma® coater. The models allow a four way coupling of momentum, heat and mass transfer in the coating process. You will see a good alignment of the models with the validation data. The results were validated along the tablet movement, coating mass distribution, outlet air temperature, tablet moisture and vapor mass fraction inside the outlet air.

Peter Böhling holds a PhD in process engineering and works at RCPE since 2012 he was recently promoted to senior scientist. His work focuses on the modeling of tablet coating processes using high fidelity CFD-DEM models, as well as the movement and behavior of complex powders in feed frames, mixers, and other unit operations. During the last year, he researched the influence of process conditions on the coating quality as well as the influence of material behavior on the residence time and mixing in different processes.

Use of Process Data for Granule Moisture Estimation in the ConsiGma® 25TM Semi-Continuous Fluid Bed Dryer

09.07.2021 – 04:00 PM CEST

This talk gives an insight into the model development for the fluid bed dryer in the ConsiGma® 25 line. You will learn which parameters have to be considered and how to best address the definition of system boundaries for mass and energy balances, ultimately obtaining a model that is suitable for integration into a process control concept. The good agreement of model prediction and measurement is demonstrated by means of validation experiments.

Jakob Rehrl is is leading the control strategy group at RCPE and his main areas of research cover continuous pharmaceutical manufacturing, process modeling, controller synthesis and control strategy development. Besides his methodological work on pharmaceutical control strategy development, he is also interested in the practical implementation of the concepts in real manufacturing lines.

Powder Tribo-charging During Twin-screw Feeding Operations and its Sensitivity to Environmental Conditions

12.07.2021 – 04:00 PM CEST

Powder tribo-charging is a complex multifactorial phenomenon, which may still occurr unexpectedly and cause problems during powder processing. This talks gives an insight on the propensity of commonly used pharmaceutical powders to acquire charge when processed. You will learn how tribocharging may be critical for powder feeding and how to characterize it, which material attributes are deemed relevant, and how it may be affected by changes in relative humidity.

Michela Beretta holds a master‘s degree in chemical engineering and is currently a PhD student at RCPE. Her research focus is the field of material science for continuous manufacturing. Within the last years she has been working on powder characterization, continuous direct compression and on the development of controlled drug delivery systems for vaginal administration.

Heat and Mass Transfer in a Pharmaceutical Coating Process

15.07.2021 – 04:00 PM CEST

With the use of coupled CFD-DEM simulations, the coating yield in a Wurster process was predicted. To increase the computational efficiency a ray tracing spray model was used. You will learn how the ray tracing model is applied to capture the effect of spray drying. Furthermore you will get an insight into which process parameters influence the coating yield and how the process can be optimized.

Stefan Madlmeir is a PhD student in chemical and process engineering since June 2018. As a scientist at RCPE he models transfer phenomena in pharmaceutical manufacturing processes. A focal point of his work are multi-scale approaches with a broad range of applicability.

Drying Process Characterization of a Novel Continuous Vacuum Drying Technology

19.07.2021 – 04:00 PM CEST

Drying is often a very challenging process and can impact the product and particle properties of the drug substance to a significant extent. This talk will give you an insight in the development and performance of a novel continuous vacuum drying technology. You will discover how particles can be dried without altering their appearance and structure, despite showing poor flow behaviour, in a truly continuous manner.

Manuel Zettl is currently finalizing his PhD in process engineering, focusing on continuous manufacturing processes for active pharmaceutical ingredients (APIs). His research focus includes continuous drying and washing, as well as particle engineering via 2D-inkjet printing and coating of solid dosage forms.

In silico Design Space Investigation of a Novel Tablet Coating Process Using Advanced Coupled Simulations

22.07.2021 – 04:00 PM CEST

This talk gives an overview how the varying process conditions can influence the drying behavior inside a ConsiGma® coater. You will discover how parameters like temperature, drying air flow rate
and spray rate influence the tablet temperature and evaporation efficiency. It will be shown how the optimal process point can be chosen using a limited in silico variance study considering the effect of the drum load, rotation rate and material properties of the tablets on the coating quality.

Peter Böhling holds a PhD in process engineering and works at RCPE since 2012 he was recently promoted to senior scientist. His work focuses on the modeling of tablet coating processes using high fidelity CFD-DEM models, as well as the movement and behavior of complex powders in feed frames, mixers, and other unit operations. During the last year, he researched the influence of process conditions on the coating quality as well as the influence of material behavior on the residence time and mixing in different processes. rotation rate and material properties of the tablets on the coating quality.

LIPID-MICROPARTICLES FOR INHALATION: Impact of lipid crystallization on spray-drying processability

26.07.2021 – 04:00 PM CEST

Spray-drying is a versatile manufacturing process that enables readily engineering of inhalable particles. However, it presents several limilations for lipid-based excipients, product loss, sticky products or simply inability to yield a solid product are typically reported. In this talk you will learn ways how this issues can be overcome and what connects the crystallization and solid state of lipidbased excipients with their processability via spray-drying.

Carolina Corzo is a chemical engineer with a master degree in pharmaceutical engineering. She‘s currently a PhD candidate in pharmacetical technology on the topic of lipid-microparticles for inhalation. She is a Scientist at RCPE in the area of „Advanced Products and Delivery“. Her main experience lays on spray-drying and material science of lipid-based excipients.

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